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<p class="MsoNormal" align="center" style="text-align:center"><b><u><span style="font-size:18.0pt">Research on Gene Therapy for Hemophilia<o:p></o:p></span></u></b></p>
<p class="MsoNormal"><span style="font-size:10.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"> <span style="font-size:10.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Times",serif">Primary Investigator: Dr. Carol Miao<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Times",serif">Location: Seattle Children’s Research Institute, 1900 9<sup>th</sup> Avenue, Seattle, WA 98101<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Times",serif">Contact: Savannah Lawton</span><span style="font-size:12.0pt;font-family:"Times New Roman",serif"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Times",serif"> <o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:.75pt;background:white"><u><span lang="EN" style="font-size:14.0pt">Short project description:</span></u><u><span style="font-size:12.0pt;font-family:"Times New Roman",serif"><o:p></o:p></span></u></p>
<p class="MsoNormal" style="margin-bottom:12.0pt"><span style="font-family:"Times",serif">Hemophilia is an X-linked bleeding disorder, that currently does not have a cure. The disease can be managed by repeated infusions of the deficient clotting factor which
is very costly and inconvenient. Furthermore, some individuals develop an immune response (antibodies) to the replacement proteins.
<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:12.0pt"><span style="font-family:"Times",serif">Our lab is currently working on gene therapy for Hemophilia A. Our main focus is development of safe and effective gene therapy protocols which will achieve high expressions
of the desired clotting factors while preventing antibody formation. <o:p></o:p></span></p>
<p class="MsoNormal"><u><span style="font-size:14.0pt">Job description:</span></u><span style="font-family:"Times",serif"><o:p></o:p></span></p>
<p class="MsoNormal">Students will learn a variety of <span class="yshortcuts">laboratory techniques</span> while assisting ongoing research, specifically in projects that involve
<b><u>Gene Therapy development</u></b> and <b><u>Immunotherapy</u></b>. Techniques include cell culture, sterile techniques, cloning, plasmid prep, microbubble prep etc. These projects require the handling of mice, including collecting blood and dissections.
Students will learn how to keep a laboratory notebook and to occasionally read scientific articles. In addition, students will assist in the daily maintenance of the lab (i.e. cleaning dishes, making up
<span class="yshortcuts">stock solutions</span>, etc). This position is ideal for an enthusiastic, detail-oriented student looking for an introduction to research.
<span style="font-size:12.0pt;font-family:"Times New Roman",serif"><o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal" style="background:white"><u><span lang="EN" style="font-size:14.0pt">Work schedule:<o:p></o:p></span></u></p>
<p class="MsoNormal"><span lang="EN">We are looking for someone to begin training during Spring quarter or early summer. Student will be expected to come in for 10-15 hours per week during the quarter, at least 4 hours per shift.</span><span lang="EN" style="font-size:12.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN">During the <b>SUMMER</b>, full time (40 hours a week, M-F) or part-time (20 hours or more) may be granted based on the PI’s discretion.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN">This is a paid position. Students will not get academic credit during summer. However, starting autumn quarter, students may get credit (499) if preferred.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span lang="EN">Length of commitment</span></b><span lang="EN"> required of student:
<i>at least </i>1 year, preferably 2 years.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN"> </span><span style="font-size:10.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span lang="EN">The ideal candidate would be
<b><u>a junior/senior in Autumn 2023</u></b> and <u>must have completed the coursework in Intro to Biology sequence</u>. (Biol 180/200/220 by end of this spring). Concurrent enrollment in Biochemistry, Molecular and Cell Biology, or Bioengineering is preferred
but not mandatory. </span>No previous research experience is required.<span style="font-size:12.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span lang="EN"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span lang="EN">If interested, please send
<b><u>Resume and Unofficial Transcript</u></b> to Savannah Lawton at <a href="mailto:Savannah.lawton@seattlechildrens.org">
Savannah.lawton@seattlechildrens.org</a> </span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Times New Roman",serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Times New Roman",serif"><o:p> </o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><b><span style="font-size:12.0pt;font-family:"Times New Roman",serif;color:green">Jason Patterson, M Ed. (He/Him)</span></b><span style="font-size:12.0pt;font-family:"Times New Roman",serif"><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:10.0pt;font-family:"Times New Roman",serif;color:green">Academic Counselor Senior, Department of Biology
</span><span style="font-size:12.0pt;font-family:"Times New Roman",serif"><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:12.0pt;font-family:"Times New Roman",serif"><a href="mailto:patterj@u.washington.edu"><span style="font-size:10.0pt;color:navy">patterj@u.washington.edu</span></a></span><span style="font-size:10.0pt;font-family:"Times New Roman",serif;color:green"> </span><span style="font-size:12.0pt;font-family:"Times New Roman",serif"><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:10.0pt;font-family:"Times New Roman",serif;color:green">318 HCK, University of Washington,
<b>BOX</b> 355320 Phone: 206-543-7767</span><span style="font-size:12.0pt;font-family:"Times New Roman",serif"><o:p></o:p></span></p>
<p class="MsoNormal"><u><span style="font-size:10.0pt;color:navy"><a href="http://www.biology.washington.edu/programs/undergraduate">http://www.biology.washington.edu/programs/undergraduate</a><o:p></o:p></span></u></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:10.0pt;font-family:"Times New Roman",serif;color:green">Biology Zoom drop-in advising hours (10-15 min meetings):<o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:10.0pt;font-family:"Times New Roman",serif;color:green">Monday - Thursday 9 a.m. - 12:00 p.m. and 1:00 p.m. - 4:00 p.m.<o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:10.0pt;font-family:"Times New Roman",serif;color:green">My Regular Drop in Zoom days:
<b>Tues, Thurs 1-4 pm, and Mon, Tues, Weds, Thursday 9-12pm. </b> <o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Times New Roman",serif;color:green">Zoom link for those hours:
</span></b><span style="font-size:10.5pt;font-family:"Helvetica",sans-serif;color:#232333;background:white"><a href="https://washington.zoom.us/j/97207369544">https://washington.zoom.us/j/97207369544</a><o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Times New Roman",serif;color:green"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Times New Roman",serif;color:#763E9B;background:white">Advising Sessions Via EMAIL, PHONE, and ZOOM. In person individual advising available by appointment only.</span><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Times New Roman",serif;color:green"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><span style="font-size:12.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><u><span style="color:#0C882A">Appointments by request. Please include your name and student number in your emails.</span></u></b><i><span style="font-size:12.0pt;font-family:"Times New Roman",serif;color:green">
</span></i><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
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