[Biostudent] Undergrad Research - Miao Lab

[Jason L. Patterson]

Research on Gene Therapy for Hemophilia


Primary Investigator: Dr. Carol Miao
Location: Seattle Children's Research Institute, 1900 9th Avenue, Seattle, WA  98101
Contact: Savannah Lawton

Short project description:
Hemophilia is an X-linked bleeding disorder, that currently does not have a cure. The disease can be managed by repeated infusions of the deficient clotting factor which is very costly and inconvenient. Furthermore, some individuals develop an immune response (antibodies) to the replacement proteins.
Our lab is currently working on gene therapy for Hemophilia A. Our main focus is development of safe and effective gene therapy protocols which will achieve high expressions of the desired clotting factors while preventing antibody formation.
Job description:
Students will learn a variety of laboratory techniques while assisting ongoing research, specifically in projects that involve Gene Therapy development and Immunotherapy. Techniques include cell culture, sterile techniques, cloning, plasmid prep, microbubble prep etc.  These projects require the handling of mice, including collecting blood and dissections.  Students will learn how to keep a laboratory notebook and to occasionally read scientific articles. In addition, students will assist in the daily maintenance of the lab (i.e. cleaning dishes, making up stock solutions, etc). This position is ideal for an enthusiastic, detail-oriented student looking for an introduction to research.

Work schedule:
We are looking for someone to begin training during Spring quarter or early summer.  Student will be expected to come in for 10-15 hours per week during the quarter, at least 4 hours per shift.
During the SUMMER, full time (40 hours a week, M-F) or part-time (20 hours or more) may be granted based on the PI's discretion.
This is a paid position.  Students will not get academic credit during summer.  However, starting autumn quarter, students may get credit (499) if preferred.

Length of commitment required of student: at least 1 year, preferably 2 years.

The ideal candidate would be a junior/senior in Autumn 2023 and must have completed the coursework in Intro to Biology sequence. (Biol 180/200/220 by end of this spring). Concurrent enrollment in Biochemistry, Molecular and Cell Biology, or Bioengineering is preferred but not mandatory. No previous research experience is required.

If interested, please send Resume and Unofficial Transcript to Savannah Lawton at Savannah.lawton at seattlechildrens.org<mailto:Savannah.lawton at seattlechildrens.org>


Jason Patterson, M Ed. (He/Him)
Academic Counselor Senior, Department of Biology
patterj at u.washington.edu<mailto:patterj at u.washington.edu>
318 HCK, University of Washington, BOX 355320 Phone: 206-543-7767
http://www.biology.washington.edu/programs/undergraduate
Biology Zoom drop-in advising hours (10-15 min meetings):
Monday - Thursday 9 a.m. - 12:00 p.m. and 1:00 p.m. - 4:00 p.m.
My Regular Drop in Zoom days:  Tues, Thurs 1-4 pm, and  Mon, Tues, Weds, Thursday 9-12pm.
Zoom link for those hours: https://washington.zoom.us/j/97207369544

Advising Sessions Via EMAIL, PHONE, and ZOOM. In person individual advising available by appointment only.


Appointments by request.  Please include your name and student number in your emails.

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